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Study 7 was a 64-week trial that enrolled 307 patients with obesity (BMI greater than or equal to 30 kg/m2) or with overweight (BMI 27-29.9 kg/m2) and at least one weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension

Medicare does not cover GLP-1s for weight loss or isolated NASH due to the statutory exclusion of weight-loss drugs

doi: 10.1186/s12902-020-00563-y 66 LiuTLiuC-AZhangQ-SZhangQWangY-MSongM-Met al

Similarly, body mass index (BMI) can guide dosing decisions patients with higher BMIs may need larger maintenance doses to achieve effective weight loss

The most common gastrointestinal symptoms include: Nausea (1220% of patients): Usually mild to moderate, most pronounced 13 days after injection, typically improving within the first month Diarrhea (716% of patients): Often resolves as the body adjusts to the medication Decreased appetite : An expected pharmacologic effect that contributes to weight loss Constipation (57% of patients): May require dietary fiber adjustments or stool softeners Vomiting (28% of patients): Less common but warrants medical attention if persistent Abdominal discomfort or bloating : Related to delayed gastric emptying Most gastrointestinal side effects are mild to moderate in severity and diminish significantly after 48 weeks as tolerance develops

Still, its difficult to know just how many people are using peptide therapy today