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Keep a diary of food, new medications, recent illnesses, and activities in the 48 hours before each episode

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the peak plasma level of the active metabolite is typically achieved an hour after oral administration

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Mice were placed in a stereotaxic frame (Kopf Instruments, USA), and a rectangular craniotomy was performed over the medial prefrontal cortex (AP, 13 mm and ML, 01.5 mm from the bregma) using a dental drill (Microtorque II, Ram Products, USA)