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Each dose bump deepens appetite suppression, further reducing calorie intake and intensifying that tired-at-the-gym feeling

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Nat Rev Drug Discov 21(3):201223 Kanoski SE et al (2011) Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4

Robert Kushner: Well, we're targeting a sweet spot in our biology, Mike, that we didn't really know was there, at least I didn't know what was there

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