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Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158
About 1/3 experienced diarrhea
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Conclusions/interpretation Glutamine acts as a trigger and potentiator of GLP-1 release, consistent with its role as the major metabolic fuel for the gut
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Cardiovascular outcome studies have shown cardiovascular advantages associated with certain GLP-1 receptor agonists, especially in those with pre-existing cardiovascular illness
