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There is also preclinical evidence that GLP-1RAs may directly modulate pain through reduction of central sensitization, suggesting the possibility of additional symptomatic improvement for IIH patients with headache (32)

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Researchers caution the findings are exploratory, the sample was small, and further trials are needed before conclusions extend to the broader population

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The Nrf2/HO-1 pathway plays a vital role in antioxidative and iron-homeostatic responses, exhibiting a well-documented double-edged sword effect in ferroptosis regulation

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