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[9] [5] This varies considerably: dulaglutide (Trulicity) for 14 days, liraglutide (Victoza/Saxenda) for 30 days, and semaglutide (Ozempic/Wegovy) for 6 weeks
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Incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), both play important roles in triggering the pancreas to secrete insulin to achieve normal glucose homeostasis, however, for people with diabetes, the pancreas becomes less responsive to incretins (predominately to GIP)
The preparation is standardised prior to use, allowing researchers to work with a consistent peptide composition and eliminating variability associated with solution preparation