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The authors suggested that larger doses could contribute to blood pressure fluctuations, fluid loss and disturbances in autonomic nervous system function, which controls automatic processes such as heart rate and blood vessel regulation
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One is GLP-1 receptor (GLP-1R) agonists that mimic GLP-1 action but are resistant to DPP-4 degradation, and another is DPP-4 inhibitors that block GLP-1 degradation and thus prolong the activity of endogenously expressed native GLP-1
Together, these actions help keep blood sugar steady and reduce overeating
At the ASGCT 2025 meeting, Fractyl presented data showing low systemic circulating GLP-1 levels with their approach