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Published 2022 Aug 23
Then came a scary incident
The Ipswich Touch Test is a valid, reliable and easy-to-use screening tool for diabetic peripheral neuropathy
With doses of 10 nmol/kg and higher, rats exhibited not only a lack of activity, but also notable changes in facial expressions associated with pain and nausea including orbital tightening and nose/cheek flattening compared to rats treated with vehicle alone
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The fact that NRF2 is readily inducible in cultured astrocytes suggests that most pharmacological NRF2 activators may specifically target astrocytes in vivo, although there is still limited direct evidence for this
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