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Current animal model systems do not fully recapitulate the pathophysiological conditions in human IC/BPS, and targeting specific molecular pathway disruption in animal models might serve as a better option than existing models

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VEGF tumorigenesis was avoided and counteracted (Sikiric et al., 1997c), and inhibition of the growth of several tumor lines and counteraction of tumor cachexia (Kang et al., 2018) and counteraction of the uncontrolled cell proliferation (Ki-67 overexpression counteracted) (Sever et al., 2019) were observed

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