As the tablet erodes, SNAC helps create a very local micro-environment that buffers/raises pH right around the dissolving tablet, reducing enzymatic breakdown in the stomach, and temporarily increases transcellular uptake across the gastric epithelium (think: a brief, reversible permeability boost) so semaglutide can slip through
However, their therapeutic effects extend beyond glycemic control, particularly in weight management and metabolic disorders
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Tirzepatide may feel stronger early, while semaglutide may feel milder at first