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And the oral GLP-1 era is going global: the EMA recommended the Wegovy pill for EU approval in May, with Novo planning launches in select markets outside the US in the second half of 2026, while Lilly has submitted Foundayo for approval in more than 40 countries and plans to launch in each market shortly after regulatory clearance

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Collectively, SGLT2i-GLP-1RA combination therapy significantly improved BP control, independent of the order in which the agents were initiated

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This outcome is thought to be an effect of all medications that increase GLP-1, because of both an increase in SDF-1-alpha and capillary density due to increased hypoxia-inducible factor 1-alpha and vascular endothelial growth factor

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