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How GLP-1s Work in the Body Slow gastric emptying (food stays in the stomach longer) Increase satiety signals to the brain Reduce appetite and overall intake Improve insulin response and glycemic control While these effects support metabolic health, slower digestion is also what sets the stage for GI symptoms, including reflux. Digestive Impact of GLP-1s: What the Research Shows Increased Upper GI Symptoms One of the most consistent findings across GLP-1 clinical trials is the high rate of gastrointestinal side effects
Retatrutide is not an approved treatment, and any reference to dose or dosage is for educational purposes only
Farxiga and Jardiance are recommended as treatment options for people with type 2 diabetes by the American Diabetes Association
Common Side Effects Feeling sick (nausea) Diarrhoea Constipation Being sick (vomiting) Indigestion, bloating or wind Tiredness and headache Less Common but More Serious Speak to your prescriber or a pharmacist if side effects are severe or do not settle
Biochim Biophys Acta (BBA)-Biomembranes (1976) 419:118
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