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No studies had been reported on trapping AP sites and inhibiting APEI-mediated AP sites repair for the treatment of thyroid cancer

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In addition the recombinant proteins were also found to withstand four cycles of freeze and thaw without losing activity

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Other negative modulators of NRF2 are: CR6-interacting Factor 1 (CRIF1), a protein previously known as a cell cycle regulator and transcription cofactor, which is able to negatively regulate NRF2 protein stability under both reducing and OS conditions through physical interaction with both N- and C-terminal regions of NRF2 [229]