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Insulin is essential for patients, particularly those with type 1 diabetes or advanced type 2 diabetes, where the body cannot produce enough insulin

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(4) This may lead to elevated levels of plasma growth hormone and insulin-like growth factor 1 (IGF-1)

Predicted properties of natural homologues As described in the main text, we used our multi-task neural-network ensemble model to make predictions for natural GCG and GLP-1 peptide orthologues that are found in various organisms, identified using BLASTp to search the NCBI RefSeq 49 database to identify non-redundant proglucagon sequences from various organisms across diverse phylogenetic groups

Their highly conserved regulatory, kinase, and association domains make isoform selectivity a key challenge, as each has distinct tissue-specific functions, and off-target inhibition may cause toxicity

It also regulates blood pressure and cholesterol levels