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Jacoba KG, Abarquez RF, Topacio GO, and et al
Without intrinsic factor, the B12 in your diet simply passes through your digestive system unabsorbed
The body produces hundreds of them naturally, and each carries a fairly specific instruction: regulate this hormone, stimulate this repair pathway, modulate this metabolic process, trigger this sleep-cycle response
One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect
So, improving sleep deprivation is also one of the core benefits of vitamin B12 injections
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