Athletes using these medications should work closely with sports medicine providers, consider body composition tracking beyond just weight, maintain high protein intake even with reduced appetite, prioritize resistance training, and monitor performance metrics to catch excessive muscle loss early
Glycemic improvement with a fixed-dose combination of DPP-4 inhibitor + metformin in patients with type 2 diabetes (GIFT study)
Tirzepatide, for example, works through both GLP-1 and GIP pathways and is FDA-approved for chronic weight management in qualifying adults, in addition to a reduced-calorie diet and increased physical activity
Another small trial in obese hypogonadal men compared liraglutide vs testosterone gel over 16 weeks: the liraglutide group lost ~6% body weight and showed rising LH/FSH and SHBG (as mentioned earlier), whereas the testosterone therapy group gained lean mass but lost some endogenous gonadal function
By slowing gastric motility, bremelanotide is thought to reduce the oral absorption (bioavailability) of certain medications, such as naltrexone and indomethacin
But the risk increases when taken with other diabetes medications that do
