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In ACHIEVE-1 , the first of seven Phase 3 studies in people with type 2 diabetes, orforglipron reduced A1C by an average of 1.3% to 1.6% across doses compared to placebo at 40 weeks, starting from a baseline of 8.0%
These agents are FDA-approved primarily for the management of type 2 diabetes mellitus and, for specific products (Wegovy, Saxenda, Zepbound), for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity
J Inherit Metab Dis 2004
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It is becoming increasingly obvious that treating obesity also requires a multimodal approach that combines lifestyle interventions, pharmacotherapy, and bariatric surgery to achieve the tailored weight loss and metabolism goals needed for long-term health gain
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