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Aunque la evidencia preclnica sugiere efectos cardioprotectores, los beneficios cardiovasculares demostrados clnicamente provienen de estudios con agonistas del receptor de GLP-1 especficos (como liraglutida, semaglutida y dulaglutida), que han mostrado reduccin de eventos cardiovasculares mayores en pacientes con diabetes tipo 2

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Among the included studies, 24 utilized longitudinal designs (10 with placebo- and 10 comparator-controlled 13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32 and 4 were single armed) 33,34,35,36

This combination of biological complexity and structural resistance explains why the field stagnated for decades

NAD+ requires a different syringe and site because its acidic solution can destabilize peptides on contact

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