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Mitochondrial dysfunction itself acts as a ROS generator, resulting in a vicious cycle of ROS generation (Wu et al

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Accordingly, during the early phase of heat stress, cells primarily depend on preexisting molecular chaperones to refold, stabilize, or degrade abnormal proteins (Murshid et al., 2018

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Your liver is the primary detoxification organ, and glutathione is critical for its Phase II detox pathways