Figure 1 2.1 Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease ( 2), nitric oxide (NO), hydroxyl radical (-0H), hydroperoxyl radical (O 2 H), hydrogen peroxide (H 2 O 2 ), and singlet oxygen ( 2.2 Damage to biomolecules ROS can damage various cell biomolecules, including lipids, proteins, and DNA
Campen, Rama R
Leighton et al., 2001)
Extensive synaptic remodeling also occurs during adolescence, and CAS is known to disrupt synaptic plasticity and myelination with long-term implications for psychology, cognition and behavior (73, 279)
J Pediatr Surg 35:847851
This is the part that surprises people