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A patient already losing electrolytes through GLP-1-related vomiting who also takes HCTZ 25 mg daily faces compounded depletion

But at higher concentrations like 20mg/mL, 1 unit of dead space equals 200mcg, and 5 draws waste 1,000mcg (1mg), which is 5% of a 20mg vial

What are its benefits

Understanding an individual's genetic architecture in these pathways may support more informed medication selection and dose titration, though genetic predisposition does not determine exact treatment outcomes

Implementation of the BALANCE model in Medicare faces an uncertain future

It complements the other benefits by potentially optimizing body composition in a meaningful way