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Instead, diet-induced obese (DIO) rat assays (28 days) revealed that liraglutide regulates the neuronal expression of CART and POMC in ARC neurons, with increased CART levels but unchanged POMC expression

Exp Lung Res

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Potential direct mechanisms involve GLP-1 receptor activation on vascular endothelial cells and possibly immune cells, though human evidence for the latter is variable

Sabin, S