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GLP-1 medications significantly suppress appetite, which can lead to inadequate protein consumption during rapid weight loss

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You eat less because you're not hungry

The study also indicated that GLP-1 RA treatment was associated with a moderately increased risk of gallstones (RR: 1.27, 95% CI 1.101.47), cholecystitis (RR: 1.36, 95% CI 1.141.62), and overall gallbladder disease risk (RR: 1.55, 95% CI 1.082.22) compared to placebo