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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years
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The most common sites for B12 injections are the deltoid (upper arm), vastus lateralis (outer thigh), ventrogluteal (hip), abdomen, and outer upper arm for subcutaneous injections
[10] [12] These interactions are supported by pharmacokinetic studies, clinical observations, and drug interaction databases
Understanding these metabolic effects has implications for research into diabetes and related metabolic conditions
