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Common side effects Topical applications may cause temporary redness, tingling, or dryness at application sites
Long-term use: Clinical trials only ran 12 weeks, so long-term safety data (6+ months continuous use) comes from anecdotal reports
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(PubMed) Nurk E, Drevon CA, Refsum H, et al
Rodrigues, C
Several studies have shown that regular physical activity increases endothelial vasodilation in people who have high blood pressure and heart disease, as well as in healthy individuals (52, Studies have also shown that exercise increases antioxidant activity, which helps inhibit the breakdown of nitric oxide caused by free radicals ( The benefits of exercise on endothelial health and nitric oxide production can be seen in as little as 10 weeks when exercising for 30 minutes at least three times a week (52)
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