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The researchers examined the impact of these interventions through a biochemical characterization of brain homogenates, quantifying oxidative and inflammatory markers such as lipid peroxides, glutathione (GSH), glutathione S-transferase (GST), 5-lipoxygenase (5-LOX), cyclooxygenase-2 (COX-2), leukotriene B4, prostaglandin E2, and ascorbic acid using spectrophotometric assays and ELISA

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The effects of canagliflozin in type 2 diabetes in subgroups defined by population-specific body mass index: insights from the CANVAS program and CREDENCE trial

These changes reflect structural improvements from within rather than surface-level treatments

These findings provided external support for TCMR-associated T-cell metabolic transcriptional remodeling, although the limited number of validation biopsies precluded definitive statistical validation