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Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT)

Specific mechanisms under investigation include critical pathways involved in the generation of and protection against oxidative stress

The accumulation of misfolded proteins in the ER can trigger a stress response that leads to increased ROS production and inflammation, contributing to neuronal cell death (Fan et al., 2017

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L-theanine also has potential cardiovascular and detoxification benefits through cholesterol protection and increased glutathione levels

45(4): 7259 Mitchell ME, Snyder EA