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But pharma is taking back the wheel: Novo launched cash-pay Wegovy via NovoCare at $499/month then ended a partnership with Hims over continued off-label compounding (source) Lilly is offering Zepbound via LillyDirect while suing DTC platforms in CA (source) Hims is hedging with a ZAVA acquisition to expand GLP-1 sales in the EU (source) Most commentary stops at the what. I wanted to understand why

Simultaneous induction of Ppara and Ppargc1a underscores enhanced mitochondrial oxidative capacity, while restoration of Pex3 and Crls1 points to improved peroxisomal and mitochondrial integrity

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Weight loss itself may theoretically alter thermoregulation as adipose tissue provides insulation and affects heat dissipation

Dermatology 231 , 231238 (2015)

This happens because the tool floors decimal doses to ensure that full doses only are counted