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slower escalation schedules generally produce fewer gastrointestinal symptoms, though they delay achievement of therapeutic doses and optimal weight loss effects
Short-acting GLP-1RAs are administered before a meal, and have a greater effect on gastric emptying and postprandial glucose, primarily after the meal, whereas long-acting GLP-1RAs have less of an effect on gastric emptying and postprandial glucose excursions, but a more pronounced effect on fasting blood glucose and weight loss (140)
On small GLP-1 doses, this can represent 50-80% of the dose volume
S., Drucker, D
American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis- 2020 UPDATE
Thats just 36% of the median of 6.4 million acre-feet recorded annually between 1991 and 2020
