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When protein intake is insufficient, the body may break down muscle tissue for energy, which can result in: Weakened muscles and reduced strength A slower metabolism, making calorie burning less efficient An increased risk of regaining weight after stopping the medication Additionally, research suggests that GLP-1 therapy decreases muscle protein synthesis, meaning the body has a harder time rebuilding lost muscle
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Habitual smokers, however, showed impaired renal response following active smoking (23 mg nicotine) [89], suggesting the development of nicotine tolerance in these individuals compared to non-smokers [87]
Driessen JH
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