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Clinical profiles and treatment patterns for new users of SGLT2i or GLP-1 RA with CKD and type 2 diabetes in the earlier period (20122021) have been previously reported [17, 18]

BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia

Also, it provides major antioxidant defense mechanism by neutralizing toxic peroxides (i.e., hydrogen peroxide formed from oxygen metabolism)

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