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The high ionic strength of body fluids induces the Debye screening effect
That said, human safety data currently consists of only three small studies with no randomized controlled trials, and the longest follow-up spans just 6 to 12 months
Nonetheless, some enzymatic pathways can intensify RCS production to relatively high levels, when reactive carbonyls demonstrate detrimental effects
The main goal is to bypass the gut
For cardiovascular health: Swanson Ultra L-Carnitine Fumarate
Wongsantichon J, Ketterman AJ (2005) Alternative splicing of glutathione S-transferases
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