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Taking B12 with or without food makes little difference for standard oral supplements in individuals with normal gastrointestinal function

Sufficient B12 in the diet lowers the risk of age-related macular degeneration

Journal of Clinical Medicine , 9 (2), 474

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Some individuals may experience headache, nausea, pruritus, acneiform eruptions, or dizziness

By influencing S-adenosylmethionine (SAM) levels, it also plays a role in epigenetic regulation and longevity-related gene expression, linking energy metabolism with cellular lifespan