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Higher doses and more complex formulations also increase cost
As a follow-up to Lehninger's work several years later, Nishikimi and co-workers observed that the gene that codes for gulonolactone oxidase is actually present in humans, but is not active due to the accumulation of several mutations that turned it into a non-functional pseudogene (Nishikimi & Yagi 1991)
2025;8(1):e2457349
GPx4 is also considered a tumor suppressor because it is down-regulated in tumors [23, 43]
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