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Glutamatergic theories of schizophrenia are based on the ability of N-methyl-D-aspartate receptor (NMDAR) antagonists to induce schizophrenia-like symptoms, as well as emergent literature documenting disturbances of NMDAR-related gene expression and metabolic pathways in schizophrenia

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However, the evidence is mixed

The dataset used in this study was extensive, encompassing various aspects of patient information including demographic details, diagnoses (according to International Classification of Diseases, Tenth Revision, Clinical Modification [ICD-10-CM] codes), procedures (classified according to the International Classification of Diseases, Tenth Revision, Procedure Coding System [ICD-10-PCS] or Current Procedural Terminology), and medications (coded as per the Veterans Affairs National Formulary)