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Notably, derivatives bearing L-sugar configurations outperformed their D-sugar counterparts, for instance, 3-O-(2,3,4-tri-O-acetyl--L-glucopyranosyl)-caudatin (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) (Li X
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In the European Union, the Food Safety Authority (EFSA) relies on the Qualified Presumption of Safety (QPS) approach for microorganisms in foods and has issued strict guidance on health claims, which, in practice, has made approval of probiotic health claims very difficult
The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] , indicating that cysteine may be a limiting substrate for GCL