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Strengths of the present meta-analysis are the inclusion of all CVOTs published by 10 December 2021, the very large number of participants, the high quality of the trials which minimizes the risk of bias, and the absence of significant heterogeneity in most analyses, which ranged from absent to low or moderate
However, depletion of glutathione using buthionine sulfoximine during hypoxic exposure increases the number degenerating cells in hippocampus
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Since its original description by James Parkinson in 1817 [2], remarkable progress has been made in the symptomatic management of PD, from the discovery of levodopa in the late 1960s [3] to current advanced therapies, such as deep brain stimulation and magnetic resonance imaging (MRI)-guided focused ultrasound [4]
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