It has been suggested that A accumulation in the brain may be given by the fact that this peptide acts as an antimicrobial peptide (AMP) related to innate immunity (Fulop et al., 2018)
However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])
May 12 2022;22(1):131
We reviewed the latest evidence available, which includes: 1 systematic review, 1 narrative review, 1 general review and 1 pilot study in humans
Diabetes Care 2005;28:89-94
Drinking plenty of water throughout the day helps keep your skin cells plump and resilient, which can diminish the appearance of fine lines and give your skin a healthier, more supple look