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Dehydration, inadequate protein intake, sleep deprivation, and underlying thyroid or electrolyte disorders can all cause or worsen fatigue
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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)
Collectively, experimental PPAR agonists demonstrate some efficacy in NAFLD but their use might be hobbled by adverse effects attributable to PPAR and PPAR activation
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Navarro, F
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