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In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]
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However, glutathiones long-term safety and efficacy are a part of ongoing research as scientific evidence stems from smaller clinical trials
298 , E141E145 (2010)
The allosteric regulators of GLUD1 - ADP, GTP, Leu, NAD + and NADH - exert their effects by changing the energy required to open and close the catalytic cleft during enzymic turnover, in other words by destabilizing or stabilizing, respectively, the abortive complexes
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