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GLP-1 medications are not recommended during pregnancy or breastfeeding
3B), and TWIST1 (Fig
De la dcouverte des hormones incrtines aux doubles et triples agonistes GIP / GLP-1 / glucagon From the discovery of incretin hormones to GIP / GLP-1 / glucagon double and triple agonists 1 Service de diabtologie, CHU Piti-Salptrire, Paris, France 2 Universit Paris-Diderot, Unit de biologie fonctionnelle et adaptative / CNRS UMR 8251, Paris, France * Rsum Lide de traiter les diabtes sucrs par des hormones intestinales a t propose ds les dbuts de lendocrinologie, en 1902, mais ne sera mise en pratique quau dbut des annes 2000
PloS One (2013) 8(3):e58784
Fatigue affects 5-11% of patients and typically results from substantial caloric restriction due to appetite suppression, gastrointestinal side effects like nausea and vomiting, dehydration from reduced oral intake, or rapid metabolic changes during weight loss
Practical recommendations for safe concurrent use include: Take melatonin exactly as prescribed by your doctor (typically Circadin 2mg modified-release tablet) Take melatonin at a consistent time each evening to support circadian rhythm regulation Monitor for any unusual side effects, particularly increased drowsiness or gastrointestinal symptoms If you have diabetes, check blood glucose levels more frequently when first combining these medicines Maintain a sleep diary to track whether melatonin is effectively improving your sleep quality Melatonin may cause drowsiness
