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doi: 10.1111/j.1750-3639.2004.tb00090.x 23 BuhlRBarthHHugoHHMautnerVFMehdornHM
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this is plausible but not well quantified for semaglutide-specific pathways
However, pharmacokinetic studies suggest that these comorbidities do not affect the pharmacokinetics of oral semaglutide, and based on the observed safety profiles, no dose adjustments are recommended [68, 69]
glucagon receptor agonism may further amplify heart rate elevation
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