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57 (2), R93R108
Trends in glucagon-like peptide 1 receptor agonist use, 2014 to 2022
Shima Hadidchi
Pattern 2: The Non-Responder (approximately 15% of switchers) Weight loss plateaus or slows despite escalating to Zepbound 12.5 to 15 mg May report initial response at 5 to 7.5 mg that fades by week 16 to 20 Often have underlying metabolic factors (severe insulin resistance, hypothyroidism, medications causing weight gain) For this group, the switch to tirzepatide does not solve the core problem
Collagen remains primarily valuable for its structural protein benefits, not as a GLP-1 support supplement
A phase 2 trial
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