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The sensitivity of the quantification is high: 0.35 M for NAD + and NADP + , 0.28 M for NADH and NADPH, 72 M for the GSH pool and 10 M for GSSG (Supplementary Figure 1s)
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46 High intratumoral expression of CYP3A4 can accelerate the metabolic inactivation of chemotherapeutic agents such as paclitaxel and docetaxel, thereby reducing local drug bioavailability, diminishing therapeutic efficacy, and ultimately contributing to drug resistance
ATP6AP1 associates with the V 0 sector of lysosomal v-ATPase, and its loss impairs lysosomal acidification v-ATPases are present in multiple cellular locations as proton pumps, such as the plasma membrane, Golgi-derived and secretory vesicles, endosomes and lysosomes 27
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