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Demar S, Kothari A, Calcutt NA, Fernyhough P
M.DeFrancesM
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)
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Armoni M, Harel C, Bar-Yoseph F, Milo S, Karnieli E (2005) Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements
According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects
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