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Proper application technique, dosing, and timing determine whether you see results

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Although Hanes breakthrough performance could have been due to an assortment of other factors (such as improved training), he did speed up his marathon time by nearly 6%an improvement most experienced marathoners would die for

Particle-bound glutathione-S-transferases [PMID: 499180] Laboratory literature summary: Particle-bound glutathione-S-transferases

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Not necessary, but refrigeration is acceptable if it prevents temperature fluctuations (never freeze)