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The SUMMIT trial, published in the New England Journal of Medicine in 2024, found that tirzepatide reduced the combined risk of cardiovascular death and worsening heart failure events in adults with HFpEF and obesity
Although older adults and diabetic patients often experience more GI AEs, the perceived benefits of GLP-1RAs (e.g., glycemic control, cardiometabolic risk reduction) may outweigh discomfort for this group [30,31]
WGCNA moduletrait associations and the SEA-AD lymphocyte-vs-dementia analysis used logistic regression versus a null model with two-sided likelihood-ratio tests
K., Park, G
Studies with genetically encoded sensors for Ca 2+ cycling and SV exocytosis revealed the core roles of mitochondria in presynaptic Ca 2+ clearance [54, 55]
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