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Neither the disulfide lipoic acid (LA) nor GSSSG worked in this manner, and thus served as reliable controls in the high-dose experiments (Figure 1e bars 47 and Figure 2c,d)
While some drugs target transport proteins, the development of specific and efficient drugs remains a formidable challenge, particularly given the unique structural features of membrane proteins
Most pharmacology summaries describe steady state at about 4 to 5 weeks at a given dose, with full washout taking roughly 30 days (about five half-lives) after the last dose
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