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Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy
More recent Phase 3 data from the REDEFINE 1 trial showed Cagrilintide monotherapy producing 11.8% weight loss over 68 weeks
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These results support that manipulations of TGF 1 or therapies to target SMAD3 may be potential therapeutic targets to treat ALF patients who have the potential to develop HE
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