AOD-9604 AOD-9604 is primarily recognized for its potential to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (the transformation of non-fatty foods into body fat)
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Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized
Full growth hormone administration can stimulate cortisol production through various mechanisms, and elevated cortisol is well-documented to increase appetite, particularly for high-calorie comfort foods, and promote abdominal fat accumulation
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This can cause heartburn, discomfort, and sometimes require medication or further treatment